Sudden onset of the blastic phase of chronic myelogenous leukemia
نویسندگان
چکیده
منابع مشابه
CardiacTamponade in the Myelogenous Blastic Crisis of Chronic Leukemia
A S6-year-old man with Philadelphia chromosome-positive chronic myelogenous leukemia (CML) developed hemorrhagic pericarditis with tampbnade as a terminal manifestation of the blastic risis. Cftrdiac tamponade should be kept in mind as an uncommon cause of death of CML patients. Based on a literature review, Symptornatic pericarditis in patients with CML blast crisis suggests imminent death. Th...
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In chronic myelogenous leukemia (CML), the mature granulocytes originate from a stem cell line harboring an abnormal chromosome, therefore it is possible that metabolic-functional abnormalities occur in the morphologically mature cells. In the present study, the phagocytic activity including intracellular killing, nitro blue tetrazolium (NBT) reduction, and phagocytosis were studied in 37 CML p...
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The surface antigen phenotype of 30 patients with the blast phase of chronic myeloid leukemia (CML) was determined using a panel of monoclonal antibodies recognizing differentiation antigens of normal myeloid, erythroid, megakaryocyte, and lymphoid cells. Ten patients' cells expressed a phenotype corresponding to an immature myeloid cell and were felt to have "myeloid" blast crisis. None of the...
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A 29-year-old man with an 8-year history of chronic myeloid leukemia (CML) was referred to our institution for marked leukocytosis and 3% blasts (white blood cells [WBC], 338.7 3 10/L; neutrophils, 159.2 3 10/L; myelocytes, 88.1 3 10/L; basophils, 47.43 10/L) (panel A). Cytogenetic studies showed t(9;22)(q34;q11.2), and the diagnosis of CML, chronic phase, was confirmed. The treatment history i...
متن کاملBiological properties and growth in SCID mice of a new myelogenous leukemia cell line (KBM-5) derived from chronic myelogenous leukemia cells in the blastic phase.
The establishment and the biological properties of a new leukemic cell line (KBM-5) derived from a patient in the blastic phase of chronic myelogenous leukemia are described. The cells exhibited multiple copies of the Philadelphia chromosome, and a high level of p210Bcr-Abl kinase activity was detected with rabbit anti-Abl and anti-Bcr (exon 3) peptide antisera. Use of specific primers and poly...
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ژورنال
عنوان ژورنال: Cancer
سال: 2003
ISSN: 0008-543X,1097-0142
DOI: 10.1002/cncr.11477